选择性 TYK2抑制剂。百时美施贵宝的科学家们设计 deucravacitinib 来选择性地靶向 TYK2，从而抑制 IL-23、IL-12 和 I 型干扰素（IFN）的信号传导，而这些细胞因子都是参与多种免疫介导疾病发病机制的关键细胞因子。Deucravacitinib 通过与 TYK2 的调节结构域结合实现高度选择性，促成对 TYK2 及其下游功能的变构抑制。在生理浓度范围内，deucravacitinib 选择性地抑制 TYK2。在治疗剂量下，deucravacitinib 不会抑制JAK1、JAK2 或 JAK3。 参考资料： [1]. Bristol Myers Squibb. Effectiveness and Safety of BMS-986165 Compared to Placebo and Active Comparator in Participants with Psoriasis (POETYK PSO-1).https://clinicaltrials.gov/ct2/show/NCT03624127. NLM identifier: NCT03624127. [2]. Bristol Myers Squibb. An Investigational Study to Evaluate Experimental Medication BMS-986165 Compared to Placebo and a Currently Available Treatment in Participants with Moderate-to-Severe Plaque Psoriasis (POETYK-PSO-2).https://clinicaltrials.gov/ct2/show/NCT03611751. NLM identifier: NCT03611751. [3]. Michalek, I. M., Loring, B. & John, S. M. Global report on psoriasis. (2016). Geneva, Switzerland: World Health Organization. [4]. Langley RGB et al. Psoriasis: epidemiology, clinical features, and quality of life.Ann Rheum Dis.2005;64(Suppl II):ii18–ii23. doi: 10.1136/ard.2004.033217. [5]. Pariser et al. A multicenter, non-interventional study to evaluate patient-reported experiences of living with psoriasis.J Dermatolog Treat.2015;27(1):19-26. doi: 10.3109/09546634.2015.1044492. [6]. Kimball A.B. et al. Psoriasis: is the impairment to a patient's life cumulative?J Eur Acad Dermatol Venereol.2010 Sep;24(9):989-1004. doi: 10.1111/j.1468-3083.2010.03705. [7]. Menter A et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics.J Am Acad Dermatol.2008 May;58(5):826-50. doi: 10.1016/j.jaad.2008.02.039. [8]. Ortonne JP, Prinz JC. Alefacept: a novel and selective biologic agent for the treatment of chronic plaque psoriasis. Eur J Dermatol. 2004 Jan-Feb;14(1):41-5. PMID: 14965795. [9]. National Psoriasis Foundation. Psoriasis Statistics.https://www.psoriasis.org/psoriasis-statistics/. Accessed September 8, 2021. [10]. Griffiths C & Barker J. Pathogenesis and clinical features of psoriasis.Lancet. 2007 Jul 21;370(9583):263-271. doi: 10.1016/S0140-6736(07)61128-3. [11]. Alwan W et al. Pathogenesis and treatment of psoriasis: exploiting pathophysiological pathways for precision medicine.Clin Exp Rheumatol.Sep-Oct 2015;33(5 Suppl 93):S2-6. [12]. Mahil S, Capon F & Barker J. Update on psoriasis immunopathogenesis and targeted immunotherapy.SeminImmunopathol. 2016 Jan;38(1):11-27. doi: 10.1007/s00281-015-0539-8. [13]. Horn EJ et al. Are patients with psoriasis undertreated? Results of National Psoriasis Foundation survey.J Am Acad Dermatol. 2007;57:957-962. [14]. Armstrong A. et al. Under-treatment of patients with moderate to severe psoriasis in the United States: analysis of medication usage with health plan data.Dermatol Ther (Heidelb).2017 Mar; 7(1): 97–109. [15]. Hrehorow, E et al. (2012). Patients with psoriasis feel stigmatized,Acta Derm Venereol.92(1):67-72. doi:10.2340/00015555-1193. [16]. Armstrong A, Harskamp C & Armstrong E. The association between psoriasis and obesity: a systematic review and meta-analysis of observational studies.Nutr Diabetes.2013. Dec 3;2(12):e54. doi: 10.1038/nutd.2012.26. [17]. Dubertret L et al. European patient perspectives on the impact of psoriasis: the EUROPSO patient membership survey.Br J Dermatol.2006 Oct;155(4):729-36. [18]. Oliveira, M., Rocha, B., & Duarte, G. V. Psoriasis: classical and emerging comorbidities.Anais brasileiros de dermatologia. Jan-Feb2015; 90(1), 9–20. https://doi.org/10.1590/abd1806-4841.20153038. [19]. Neimann A et al. Prevalence of cardiovascular risk factors in patients with psoriasis.J Am Acad Dermatol. 2006;55(5), 829–835. https://doi.org/10.1016/j.jaad.2006.08.040. [20]. Lebwohl MG et al. US Perspectives in the Management of Psoriasis and Psoriatic Arthritis: Patient and Physician Results from the Population-Based Multinational Assessment of Psoriasis and Psoriatic Arthritis (MAPP) Survey.Am J Clin Dermatol. 2016 Feb;17(1):87-97. doi: 10.1007/s40257-015-0169-x. [21]. Lebwohl MG et al. Patient perspectives in the management of psoriasis: results from the population-based Multinational Assessment of Psoriasis and Psoriatic Arthritis Survey.J Am Acad Dermatol. 2014 May;70(5):871-81.e1-30. doi: 10.1016/j.jaad.2013.12.018. 来源：金色财经lg...
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